Hypogonadism is common in men with myopathies.
J Clin Neuromuscul Dis
; 9(4): 397-401, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18525423
ABSTRACT
BACKGROUND:
Hypogonadism has been described in patients with myotonic muscular dystrophy type 1 but has not been evaluated in other myopathies.METHODS:
We measured total and free serum testosterone levels in 59 men with myotonic muscular dystrophy type 1 (N = 12), facioscapulohumeral muscular dystrophy (N = 11), dystrophinopathy (N = 12), metabolic myopathy (N = 7), and inclusion body myositis (N = 17) and compared these with the normal reference interval.RESULTS:
Thirty-two of the 59 (54%) participants had low total testosterone, 23 (39%) had low total and free values, and 5 (8%) had low free with normal total levels. There were no significant differences in the prevalence of hypogonadism between those with myotonic muscular dystrophy type 1 and the other groups even after considering age as a confounder.CONCLUSIONS:
Hypogonadism is common in men with myopathies, and with the importance of testosterone in the maintenance of muscle mass, treatment of hypogonadism should be considered.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testosterona
/
Hipogonadismo
/
Doenças Musculares
/
Distrofias Musculares
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Clin Neuromuscul Dis
Assunto da revista:
FISIOLOGIA
/
NEUROLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Canadá