Angiotensin blockade and matrix synthesis by glomerular epithelial cells in high glucose: a further experimental insight into the pathophysiology of diabetic nephropathy.
Clin Ter
; 159(3): 151-4, 2008.
Article
em En
| MEDLINE
| ID: mdl-18594743
ABSTRACT
AIMS:
Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor-1 (AT-1) antagonists are used in the treatment of proteinuria of diabetic nephropathy. One of the major pathogenic events in this condition is represented by the alteration of the extracellular matrix protein synthesis by glomerular epithelial cells. MATERIALS ANDMETHODS:
We evaluated the effects of the angiotensin converting enzyme inhibitor, Enalaprilat, and the AT-1 receptor antagonist, Losartan, on mRNA fibronectin and laminin synthesis by glomerular epithelial cells, in conditions mimicking hyperglycemia.RESULTS:
In high glucose conditions, Enalaprilat reduced significantly the mRNA expression of fibronectin (p 0.03), but not significantly that of laminin. Losartan addition to high glucose incubated cells reduced (-30%) mRNA expression of fibronectin, and significantly (p 0.05) the mRNA expression of laminin.CONCLUSIONS:
In addition to the known hemodynamic effects, the improvement of renal function in diabetic patients treated with these compounds may also be due to a modulator effect on extracellular matrix content and composition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Enzima Conversora de Angiotensina
/
Enalaprilato
/
Fibronectinas
/
Laminina
/
Losartan
/
Bloqueadores do Receptor Tipo 1 de Angiotensina II
/
Nefropatias Diabéticas
/
Células Epiteliais
/
Matriz Extracelular
/
Glomérulos Renais
Limite:
Animals
Idioma:
En
Revista:
Clin Ter
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Itália