Error-specific medial cortical and subcortical activity during the stop signal task: a functional magnetic resonance imaging study.
Neuroscience
; 155(4): 1142-51, 2008 Sep 09.
Article
em En
| MEDLINE
| ID: mdl-18674592
ABSTRACT
The ability to detect errors and adjust behavior accordingly is essential for maneuvering in an uncertain environment. Errors are particularly prone to occur when multiple, conflicting responses are registered in a situation that requires flexible behavioral outputs. Previous studies have provided evidence indicating the importance of the medial cortical brain regions including the cingulate cortex in processing conflicting information. However, conflicting situations can be successfully resolved, or lead to errors, prompting a behavioral change in the observers. In particular, how does the brain use error signals specifically to adjust behavior on the fly? Here we employ a stop signal task (SST) to elicit errors approximately half of the time in high-conflict trials despite constant behavioral adjustment of the observers. Using functional magnetic resonance imaging, we show greater and, sequentially, less activation in the medial cortical regions when observers made an error, compared with when they successfully resolved high-conflict responses. Errors also evoked greater activity in the cuneus, retrosplenial cortex, insula, and subcortical structures including the thalamus and the region of the epithalamus (the habenula). We further showed that the error-related medial cortical activities are not correlated with post-error behavioral adjustment, as indexed by post-error slowing (PES) in go trial reaction time. These results delineate an error-specific pattern of brain activation during the SST. The results also suggest that the relationship between error-related activity and post-error behavioral adjustment may be more complicated than has been conceptualized by the conflict monitoring hypothesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desempenho Psicomotor
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Encéfalo
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Imageamento por Ressonância Magnética
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Conflito Psicológico
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Inibição Psicológica
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Neuroscience
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos