Changes in regulation of cell-cell adhesion during tumor transformation.
Biochemistry (Mosc)
; 73(7): 742-50, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18707582
ABSTRACT
Cadherin-mediated cell-cell adhesion defines the integrity of most tissues. Cell-cell adherens junctions are dynamic structures whose functional state is regulated by interactions of cadherin with beta-catenin, p120, and actin cytoskeleton structures. Small GTPases of the Rho family and GTPase Rap1 play the central role in the formation and maintenance of cell-cell adhesion. Aberrant activation of signaling pathways, transcriptional repression of the E-cadherin gene, ectopic expression of N-cadherin, and disturbances in regulation of adhesive and transcriptional functions of beta-catenin stimulate tumor progression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Neoplásica
/
Junções Aderentes
Limite:
Humans
Idioma:
En
Revista:
Biochemistry (Mosc)
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Federação Russa