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Toxicological assessment of P-9801091 plant mixture extract after chronic administration in CBA/HZg mice--a biochemical and histological study.
Petlevski, Roberta; Hadzija, Mirko; Slijepcevic, Milivoj; Juretic, Dubravka.
Afiliação
  • Petlevski R; Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Medical Biochemistry, University of Zagreb, Zagreb, Croatia. rpetlevski@pharma.hr
Coll Antropol ; 32(2): 577-81, 2008 Jun.
Article em En | MEDLINE | ID: mdl-18756913
Acute, subchronic and chronic effects of the P-9801091 plant mixture extract at a dose of 20 mg/kg body mass were assessed in serum of healthy CBA/HZg mice at 24 hours, 7 days, 3 months and 6 months of treatment (experimental group), and compared with the values obtained in the control group of untreated healthy CBA/HZg mice. The P-9801091 plant mixture extract is an antihyperglycemic preparation containing Myrtilli folium (Vaccinium myrtillus L.), Taraxaci radix (Taraxacum officinale Web.), Cichorii radix (Cichorium intybus L.), Juniperi fructus (Juniperus communis L.), Centaurii herba (Centaurium umbellatum Gilib.), Phaseoli fructus sine semine (Phaseolus vulgaris L.), Millefolii herba (Achillea millefolium L.), Mori folium (Morus nigra L.), Valerianae radix (Valeriana officinalis L.) and Urticae herba et radix (Urtica dioica L). Toxic effect of the P-9801091 plant mixture extract was assessed by the following biochemical parameters: urea, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and cholesterol. Also, histopathological examination of the kidneys, liver, spleen, pancreas, testes and lungs was performed. Results of biochemical testing performed at specified time points generally showed no statistically significant differences from control values, with the only exception of the catalytic concentration of AST in the experimental group measured on day 7, which was significantly increased as compared with the control group (p<0.05). Pathohistological examination including characteristic organ and tissue structure, and parenchyma relationship to the adjacent blood vessels and connective tissue in the examined organs revealed no major pathologic changes.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Hipoglicemiantes Limite: Animals Idioma: En Revista: Coll Antropol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Croácia País de publicação: Croácia
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Hipoglicemiantes Limite: Animals Idioma: En Revista: Coll Antropol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Croácia País de publicação: Croácia