Neocortical maturation during adolescence: change in neuronal soma dimension.
Brain Cogn
; 69(2): 328-36, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-18778882
ABSTRACT
During adolescence, cognitive abilities increase robustly. To search for possible related structural alterations of the cerebral cortex, we measured neuronal soma dimension (NSD = width times height), cortical thickness and neuronal densities in different types of neocortex in post-mortem brains of five 12-16 and five 17-24 year-olds (each 2F, 3M). Using a generalized mixed model analysis, mean normalized NSD comparing the age groups shows layer-specific change for layer 2 (p < .0001) and age-related differences between categorized type of cortex primary/primary association cortex (BA 1, 3, 4, and 44) shows a generalized increase; higher-order regions (BA 9, 21, 39, and 45) also show increase in layers 2 and 5 but decrease in layers 3, 4, and 6 while limbic/orbital cortex (BA 23, 24, and 47) undergoes minor decrease (BA 1, 3, 4, and 44 vs. BA 9, 21, 39, and 45 p = .036 and BA 1, 3, 4, and 44 vs. BA 23, 24, and 47 p = .004). These data imply the operation of cortical layer- and type-specific processes of growth and regression adding new evidence that the human brain matures during adolescence not only functionally but also structurally.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
/
Neocórtex
/
Desenvolvimento do Adolescente
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Neurônios
Limite:
Adolescent
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Adult
/
Child
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Brain Cogn
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Suíça