11beta-Hydroxysteroid dehydrogenase: a regulator of glucocorticoid response in osteoporosis.
J Endocrinol Invest
; 31(7 Suppl): 16-21, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18791346
ABSTRACT
Until recently it was assumed that there was a direct relationship between the level of glucocorticoids in the circulation and the levels within tissue. The identification and characterisation of local glucocorticoid modifying enzymes in a range of tissues however demonstrated that tissue levels of glucocorticoids can be regulated independently of circulating levels. This appears to be the case in bone where the 11beta-hydroxysteroid dehydrogenase (11beta-HSD) enzymes are expressed. Glucocorticoids are actively generated within osteoblasts by the 11beta-HSD1 enzyme and this generation increases with proinflammatory cytokines, glucocorticoids, and probably with age. Measures of enzyme activity can predict the response of bone formation markers to therapeutic glucocorticoids. This review summarises the data relating to 11beta-HSD expression and activity in human bone and describes how this has implications for age-related, inflammation-associated, and glucocorticoid-induced osteoporosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoporose
/
Osso e Ossos
/
11-beta-Hidroxiesteroide Desidrogenases
/
Glucocorticoides
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Endocrinol Invest
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Reino Unido