Development and characteristics of pannus-like soft tissue in osteoarthritic articular surface in rat osteoarthritis model.
Clin Exp Rheumatol
; 26(4): 589-95, 2008.
Article
em En
| MEDLINE
| ID: mdl-18799089
ABSTRACT
OBJECTIVES:
Pannus is invasive granulation tissue found on the articular cartilage having rheumatoid arthritis (RA). However, pannus-like tissue has also been found in osteoarthritis (OA). Our previous study showed that pannus-like tissue in OA (OA pannus) was frequently found in human OA samples. The purpose of the study is to investigate the development and the characteristics of OA pannus in a rat OA model.DESIGN:
Ligaments of the knee joint were transected in Wister rats to induce OA. The knee joints were removed at weeks 1, 2, 4 and 6, and subjected to histological study. Samples were stained with hematoxylin and eosin (HE), Safranin-O and immuno-stained for vimentin, CD34, type II collagen and MMP-3. The whole knee joint of OA rats was implanted in SCID mice and kept for a further 3 weeks. Then the histological findings were evaluated in HE sections.RESULT:
OA pannus appeared at week 2 and extend over the articular surface. OA pannus cells were positive for vimentin and/or CD34. At week 6, a part of articular surface was restored with matrix. OA pannus cells expressed MMP-3 as well as type II collagen. Histological study of rat OA knees implanted in SCID mice showed that OA pannus cells filled the joint space and invaded articular cartilage.CONCLUSIONS:
The presence of OA pannus was found in a rat OA model and its features were similar to those in human OA. OA pannus had both catabolic and reparative features, and the latter feature were speculated to be dominant in the later phase of the disease under a certain environmental condition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tíbia
/
Meniscos Tibiais
/
Cartilagem Articular
/
Osteoartrite do Joelho
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Clin Exp Rheumatol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Japão