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Determination of angiogenic factors in serum by protein array in patients with renal cell carcinoma.
Lukesová, S; Kopecký, O; Vroblová, V; Hlávková, D; Andrýs, C; Morávek, P; Cermáková, E.
Afiliação
  • Lukesová S; Charles University in Prague, Faculty of Medicine and University Teaching Hospital in Hradec Králové: Second Department of Internal Medicine, Hradec Králové, Czech Republic.
Folia Biol (Praha) ; 54(4): 134-40, 2008.
Article em En | MEDLINE | ID: mdl-18808740
Using the protein array method we determined the serum levels of a number of angiogenic factors. We identified serum levels of angiogenin, PDGF and MCP-1 (CCL2 chemokine) in serum of 32 patients with RCC, and 14 healthy volunteers by means of antibody array analysis. The patients were divided into three groups according to their disease stages (I+II, III, and IV). We found significant differences between the controls and patients with RCC both pre-operatively and post-operatively in angiogenin, PDGF and MCP-1 serum levels. The increase in angiogenin, PDGF and MCP-1 lasted in patients with RCC stages I-III even without metastases eight weeks post-operatively. The patients with stage IV RCC showed disturbed production of PDGF and MCP-1. Protein array analysis is a powerful tool for the identification of large numbers of trace proteins. Multiplex antibody array is able to provide data more precisely reflecting the nature of pathological processes.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonuclease Pancreático / Fator de Crescimento Derivado de Plaquetas / Carcinoma de Células Renais / Quimiocina CCL2 / Análise Serial de Proteínas Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Folia Biol (Praha) Ano de publicação: 2008 Tipo de documento: Article País de afiliação: República Tcheca País de publicação: República Tcheca
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonuclease Pancreático / Fator de Crescimento Derivado de Plaquetas / Carcinoma de Células Renais / Quimiocina CCL2 / Análise Serial de Proteínas Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Folia Biol (Praha) Ano de publicação: 2008 Tipo de documento: Article País de afiliação: República Tcheca País de publicação: República Tcheca