Risk genotypes and haplotypes of the GLUT1 gene for type 2 diabetic nephropathy in the Tunisian population.
Ann Hum Biol
; 35(5): 490-8, 2008.
Article
em En
| MEDLINE
| ID: mdl-18821326
ABSTRACT
OBJECTIVE:
Diabetic nephropathy (DN) is a long-term complication of both type 1 and type 2 diabetes. Genetic studies on DN have been of little help so far, since several genetic association studies have shown conflicting results. Here we report the findings of a case-control study on five SNPs in the glucose transporter 1 (GLUT1) gene. The study investigated the association of five GLUT1 genotypes and haplotypes with DN. RESEARCH DESIGN ANDMETHODS:
All subjects, 126 DN (cases) and 273 type 2 diabetes (controls), were genotyped using the polymerase chain reaction restriction fragment length polymorphism.RESULTS:
The TT and the AA genotypes of the Haell and Enh2 SNP1, increased the risk of DN. The study also identified CGT as the highest risk haplotype (4.4-fold) followed by CAT with an increased risk of DN of 2.6-fold.CONCLUSIONS:
The GLUT1 gene confers susceptibility to DN in type 2 diabetes patients in the Tunisian population.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Haplótipos
/
Predisposição Genética para Doença
/
População Negra
/
Diabetes Mellitus Tipo 2
/
Nefropatias Diabéticas
/
Transportador de Glucose Tipo 1
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Africa
Idioma:
En
Revista:
Ann Hum Biol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Tunísia