[The hand: embryology and main malformative mechanisms]. / La main: embryologie et principaux mécanismes malformatifs.
Chir Main
; 27 Suppl 1: S2-6, 2008 Dec.
Article
em Fr
| MEDLINE
| ID: mdl-18838286
ABSTRACT
Upper limb bud appears in the cervical region of the embryo during the fifth week of development. It is made of epithelia and underlying mesenchyme. Diffusible growth factors, expressed by the apical ectodermal ridge, direct the proximal-distal growth. Other factors are expressed by zone of polarizing activity and ectoderm. They induce together anterior-posterior growth and dorsal-ventral polarity of the limb bud. The development of axial skeleton pattern is controlled by transcription factors from the HOX family, which are expressed in a stripe along the proximal and distal edges of the limb bud. Embryologic mechanisms of the main hand malformations are described, as well as their known genetic or mechanical aetiologies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Deformidades Congênitas da Mão
/
Polidactilia
/
Sindactilia
/
Botões de Extremidades
/
Desenvolvimento Embrionário
/
Dedos
/
Mãos
/
Síndrome de Bandas Amnióticas
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
/
Newborn
Idioma:
Fr
Revista:
Chir Main
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
França
País de publicação:
FR
/
FRANCE
/
FRANCIA
/
FRANÇA