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The effect of gonadectomy and aromatase inhibition on the excretion of 19-nordeoxycorticosterone in rats.
Gomez-Sanchez, E P; Gomez-Sanchez, C E.
Afiliação
  • Gomez-Sanchez EP; Research Service, James A. Haley V. A. Medical Center, Tampa, FL.
J Steroid Biochem Mol Biol ; 39(2): 185-8, 1991 Aug.
Article em En | MEDLINE | ID: mdl-1888677
ABSTRACT
19-Nordeoxycorticosterone (19-norDOC) is a powerful mineralocorticoid, which has been postulated to be involved in the pathogenesis of some forms of hypertension. The urinary excretion of 19-norDOC by female rats is up to 20 times that of males. To demonstrate the influence of the gonads on the excretion of 19-norDOC, we measured the excretion of 19-norDOC in intact and gonadectomized male and female rats with and without replacement with testosterone (40 mg testosterone enanthate s.c.) or estrogen (4 mg estradiol valerate s.c.) and in intact animals receiving the aromatase inhibitor, 10-propargyl androstenedione (10-pA) (10 mg s.c.). Orchiectomy produced a significant increase in the urinary excretion of 19-norDOC in males. Testosterone treatment decreased 19-norDOC excretion by castrated males to below intact values, while estrogen administration increased its excretion. Oophorectomy had no consistent effect on 19-norDOC excretion. In oophorectomized females, testosterone administration significantly suppressed 19-norDOC excretion and estrogen replacement increased excretion slightly. 10-pA had little effect on the excretion of 19-norDOC in intact rats of either sex. In conclusion, it appears that 19-norDOC production is inhibited by testosterone, but is affected only slightly by estrogens.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Aromatase / Desoxicorticosterona / Gônadas Limite: Animals Idioma: En Revista: J Steroid Biochem Mol Biol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 1991 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Aromatase / Desoxicorticosterona / Gônadas Limite: Animals Idioma: En Revista: J Steroid Biochem Mol Biol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 1991 Tipo de documento: Article