Characterization of the mononuclear cell infiltrate and HLA-Dr expression in 19 oligodendrogliomas.
Surg Neurol
; 36(2): 119-25, 1991 Aug.
Article
em En
| MEDLINE
| ID: mdl-1891756
ABSTRACT
We have studied frozen tissue from 19 oligodendrogliomas with a panel of antibodies to lymphocytes and their subsets, macrophages, natural killer cells, and HLA-Dr antigens. Macrophages were detected in moderate numbers in 60%-100% of tumors depending on the antibody used. T lymphocytes were fewer in number than macrophages and were present in 62% of cases. Most of the T lymphocytes were of the CD8 phenotype. CD4 lymphocytes were very few in number and present in only 18%. B cells and natural killer cells were absent from all cases. HLA-Dr antigens were expressed by macrophages in all cases but never on tumor cells. The implications of these findings are that macrophages and, to a lesser extent, CD8 lymphocytes are the predominant cells infiltrating oligodendrogliomas and that they may exert cellular immune functions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligodendroglioma
/
Neoplasias Encefálicas
/
Leucócitos Mononucleares
/
Antígenos HLA-DR
/
Macrófagos
Limite:
Humans
Idioma:
En
Revista:
Surg Neurol
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Reino Unido