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Biodegradable braided poly(lactic-co-glycolic acid) urethral stent combined with dutasteride in the treatment of acute urinary retention due to benign prostatic enlargement: a pilot study.
Kotsar, Andres; Isotalo, Taina; Juuti, Hanne; Mikkonen, Joonas; Leppiniemi, Jenni; Hänninen, Venla; Kellomäki, Minna; Talja, Martti; Tammela, Teuvo L J.
Afiliação
  • Kotsar A; Department of Biomedical Engineering, Tampere University of Technology, Tampere, Finland. andres.kotsar@uta.fi
BJU Int ; 103(5): 626-9, 2009 Mar.
Article em En | MEDLINE | ID: mdl-18990149
OBJECTIVE: To evaluate, in a pilot study, the efficacy and safety of combining a braided poly(lactic-co-glycolic acid) (PLGA, a copolymer of l-lactide and glycolide) urethral stent and dutasteride in the treatment of acute urinary retention (AUR) due to benign prostatic enlargement (BPE). PATIENTS AND METHODS: Ten men with AUR due to BPE were treated as outpatients. A biodegradable braided PLGA urethral stent was inserted into the prostatic urethra, using a specially designed insertion device under visual control. Dutasteride treatment was started and the patients were followed up for 3 months after insertion of the stents. RESULTS: In all patients the stents were placed successfully with the new insertion device. All men were able to void after inserting the stent. At 1 month five patients voided freely with a low residual urine volume (<150 mL), two voided but had a high residual urine volume and a suprapubic catheter was placed, and three needed a suprapubic or an indwelling catheter before 1 month, due to AUR or comorbidities. At 3 months five patients were voiding with no problems. CONCLUSIONS: We have developed a new and effective insertion device for biodegradable braided prostatic stents. The new braided-pattern stent overcomes the earlier problems of migration and sudden breakage into large particles associated with biodegradable spiral stents. However, the mechanical properties of the new stent need to be improved and tested in a longer follow-up. We consider that this new biodegradable braided-pattern urethral stent could provide a new option in the future treatment of AUR.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Poliglicólico / Hiperplasia Prostática / Azasteroides / Stents / Retenção Urinária / Ácido Láctico / Inibidores Enzimáticos Tipo de estudo: Etiology_studies / Evaluation_studies Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: BJU Int Assunto da revista: UROLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Finlândia País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Poliglicólico / Hiperplasia Prostática / Azasteroides / Stents / Retenção Urinária / Ácido Láctico / Inibidores Enzimáticos Tipo de estudo: Etiology_studies / Evaluation_studies Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: BJU Int Assunto da revista: UROLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Finlândia País de publicação: Reino Unido