Serially regulated biological networks fully realise a constrained set of functions.
IET Syst Biol
; 2(5): 313-22, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-19045826
ABSTRACT
It is shown that biological networks with serial regulation (each node regulated by at most one other node) are constrained to direct functionality, in which the sign of the effect of an environmental input on a target species depends only on the direct path from the input to the target, even when there is a feedback loop allowing for multiple interaction pathways. Using a stochastic model for a set of small transcriptional regulatory networks that have been studied experimentally, it is further found that all networks can achieve all functions permitted by this constraint under reasonable settings of biochemical parameters. This underscores the functional versatility of the networks.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Regulação da Expressão Gênica
/
Proteoma
/
Modelos Biológicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
IET Syst Biol
Assunto da revista:
BIOLOGIA
/
BIOTECNOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos