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Expression profile of mammalian microRNAs in endometrioid adenocarcinoma.
Wu, Weiguang; Lin, Zhongqiu; Zhuang, Zhiqiang; Liang, Xinjun.
Afiliação
  • Wu W; Department of Gynecologic Oncology, the Second Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Eur J Cancer Prev ; 18(1): 50-5, 2009 Feb.
Article em En | MEDLINE | ID: mdl-19077565
MicroRNAs (miRNAs) are small noncoding RNAs of 19-24 nucleotides in length and involved in gene expression regulation. They are associated with cell proliferation, differentiation, apoptosis, and carcinogenesis. The specific expression profiles of miRNAs have been found in many human cancers, but there are few studies on endometrioid adenocarcinoma. We found the miRNA expression profile in 10 pairs of endometrioid adenocarcinoma and adjacent nontumorous endometrium using human miRNA microarray. Seventeen miRNAs exhibited higher expression and six miRNAs exhibited lower expression in endometrioid adenocarcinoma samples than those in the nontumorous samples in the microarray. Of those, the miR-205, miR-449, and miR-429 were greatly enriched; in contrast the miR-204, miR-99b, and miR-193b were greatly downregulated in adenocarcinoma tissues. The expressions of these six miRNAs were validated using real time reverse transcription-PCR. This information may provide the candidate miRNA genome for further confirming the role of miRNAs in carcinogenesis of endometrioid adenocarcinoma and potentially serving as a diagnostic or therapeutic tool in endometrioid adenocarcinoma.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Carcinoma Endometrioide / Perfilação da Expressão Gênica / MicroRNAs Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Eur J Cancer Prev Assunto da revista: NEOPLASIAS / SAUDE PUBLICA Ano de publicação: 2009 Tipo de documento: Article País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Carcinoma Endometrioide / Perfilação da Expressão Gênica / MicroRNAs Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Eur J Cancer Prev Assunto da revista: NEOPLASIAS / SAUDE PUBLICA Ano de publicação: 2009 Tipo de documento: Article País de publicação: Reino Unido