Surgical outcome in hippocampal sclerosis following selective amygdalo-hippocampectomy.
Turk Neurosurg
; 18(4): 374-9, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-19107683
ABSTRACT
OBJECTIVES:
Temporal lobe epilepsy is the most common form of intractable partial epilepsy in adults with hippocampal sclerosis accounting for the majority of cases. Selective amygdalo-hippocampectomy (SEAH) is suggested as a safe and effective surgical procedure with the advantage of a better cognitive outcome.METHODS:
We prospectively documented 56 consecutive patients with medically refractory medial temporal lob epilepsy. Candidates for surgery were determined as those with characteristic clinical and imaging findings, ictal recordings, and neuropsychological evaluation. A standard SEAH was performed and hippocampal sclerosis was histologically confirmed.RESULTS:
In our study 76.7% of patients were classified as Engel I and 62.2% as ILAE I at their last follow up. Overall, at the last follow-up, 51.8% of patients were seizure-free since surgery (Engel 1a and ILAE 1a), 25% had stopped antiepileptic treatment, and another 52% had decreased either the dosage or number of antiepileptic drugs. 86.3% of the patients with abnormality on neurocognitive tasks showed improvement at the end of the 6 months post surgery.CONCLUSION:
SEAH is a safe and effective surgical procedure without the necessity of a larger resection and further invasive methods.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Procedimentos Neurocirúrgicos
/
Hipocampo
/
Tonsila do Cerebelo
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Turk Neurosurg
Assunto da revista:
NEUROCIRURGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Turquia
País de publicação:
TR
/
TURKEY
/
TURQUIA