Prevalence of single and multiple human papillomavirus types in cervical cancer and precursor lesions in Hubei, China.
Oncology
; 76(3): 157-61, 2009.
Article
em En
| MEDLINE
| ID: mdl-19174613
ABSTRACT
OBJECTIVE:
The objective of this study was to establish the prevalence and type distribution of human papillomavirus (HPV) in cervical cancer and cervical intraepithelial neoplasia (CIN) in Hubei, China.METHODS:
A total of 112 patients with cervical cancer and 60 CIN II-III samples were obtained from women undergoing biopsy or surgery. HPV and typing were examined by the polymerase chain reaction (PCR) and sequencing.RESULTS:
HPV DNA was detected in 105 patients with cervical cancer (93.75%), HPV 16 being detected in 91 (81.25%) cases, and HPV 58 in 7 (6.25%) cases. HPV DNA was detected in 50 patients with CIN II-III (83.33%), HPV 16 being detected in 37 (61.67%) cases, HPV 58 in 5 cases (8.33%). HPV 18 was not common in this study. About 11% cervical cancer and 8.33% CIN II-III specimens exhibited multiple infections (p = 0.79).CONCLUSION:
The high prevalence of HPV 16 in Hubei, China, deserves attention as it has important implications for the usefulness of vaccine and the choice of diagnostic methods.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
/
Lesões Pré-Cancerosas
/
Neoplasias do Colo do Útero
Tipo de estudo:
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Oncology
Ano de publicação:
2009
Tipo de documento:
Article