[Absorption of fatty acids by the rat heart in arrhythmia].
Patol Fiziol Eksp Ter
; (4): 14-6, 2008.
Article
em Ru
| MEDLINE
| ID: mdl-19198266
Fifty-three white rat males were divided into 4 groups: intact, with arrhythmia, with arrhythmia treated with cordaron, with arrhythmia treated with cardiotron. The rats' diet was enriched with animal fats. Anesthesia was made with uretan (1,0-1,2 g/kg, i.p.). Arrhythmia was induced with akonitine (30-40 mg/kg, i.v.). The drugs were administered 12 and 25 days before arrhythmia induction which was registered on ECG at min 3, 5, 15 and 25 in 1, 11 and 111 standard leads. Total lipid fatty acids (TLFA) of plasma were detected in heart inflowing and outflowing blood with gas chromatography. Arrhythmia drastically changes qualitative characteristics of arterio-venous difference for fatty acids. Cordaron and cardiotron prevented arrhythmia in 63-75% cases. TLFA arterio-venous difference recovered by 55-69%. Cordaron and cardiotron may have a mediating mechanism of action on fatty acid absorption by the heart in normalization of normal heart rate in experimental arrhythmia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arritmias Cardíacas
/
Ácidos Graxos
/
Miocárdio
Tipo de estudo:
Qualitative_research
Limite:
Animals
Idioma:
Ru
Revista:
Patol Fiziol Eksp Ter
Ano de publicação:
2008
Tipo de documento:
Article
País de publicação:
Federação Russa