Synthesis of some N, n'-diacylhydrazine derivatives with radical-scavenging and antifungal activity.
Chem Biol Drug Des
; 73(3): 320-7, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19207468
ABSTRACT
A series of N,N'-diacylhydrazines were prepared and their structures were confirmed by 1H NMR, MS and FTICR-MS. They were tested radical-scavenging activity in vitro. The preliminary bioassays of title compounds showed that two compounds had excellent radical-scavenging activity comparable with vitamin C, while the activity is highly relative to the substituents. Surprisingly, several compounds also exhibit favorable fungicidal activities. To further explore the comprehensive structure-activity relationships about the fungicidal activity, a three-dimensional quantitative structure-activity relationship analysis using the method of comparative molecular field analysis was performed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sequestradores de Radicais Livres
/
Hidrazinas
/
Antifúngicos
Idioma:
En
Revista:
Chem Biol Drug Des
Assunto da revista:
BIOQUIMICA
/
FARMACIA
/
FARMACOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
China