Transdermal therapeutic systems--actual state and future developments.
Methods Find Exp Clin Pharmacol
; 13(5): 343-51, 1991 Jun.
Article
em En
| MEDLINE
| ID: mdl-1921571
ABSTRACT
Modern transdermal therapeutic systems have been marketed since the last decade only. Nitroglycerin, scopolamine, clonidine, estradiol and nicotine are the current prominent representatives that have matched expectations regarding therapeutical benefits based on TTS applications. Although different TTS constructions have been realized, it is nevertheless appropriate to consider the governing role of the skin permanent. As the upper skin barrier limits flux rates, drug uptake has to be improved by the TTS's own occlusion or by flux enhancers. Enhancers act either on the hydrophilic keratin matrix or on the lipophilic intercellular material in the stratum corneum. Improvements in drug diffusion must be balanced carefully with the risk of skin irritation. In the future we should expect, among others, pulsatile systems to avoid tolerance, or systems comprising fixed combinations of transdermal drugs within one TTS, possibly at first in the field of hormones. Other expectations will be discussed. Therapeutic benefits are expected by the administration of highly potent topical drugs by means of TTS-analogous therapeutic systems, enabling a time-controlled drug release for purposes of topical treatment only.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Administração Cutânea
/
Sistemas de Liberação de Medicamentos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Methods Find Exp Clin Pharmacol
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Alemanha
País de publicação:
ES
/
ESPANHA
/
ESPAÑA
/
SPAIN