Stilbenoids isolated from the seeds of Melinjo (Gnetum gnemon L.) and their biological activity.
J Agric Food Chem
; 57(6): 2544-9, 2009 Mar 25.
Article
em En
| MEDLINE
| ID: mdl-19222220
A 50% EtOH extract of the dried endosperms of melinjo (Gnetum gnemon L.) was purified by a combination of column chromatography, including highly porous polymer, octadecylated silica (ODS), hydroxypropylated dextran (LH-20), and silica gel, resulting in the isolation of a new stilbenoid 1, named gnetin L, along with five previously identified stilbenoids 2-6 (gnetin C, gnemonosides A, C, and D, and resveratrol). All of these stilbenoids showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity similar to that of ascorbic acid and dl-alpha-tocopherol. With the exception of gnemonoside A (3), these stilbenoids showed moderate antimicrobial activity. Inhibition of lipase from porcine pancreas was recognized in four stilbenoids excluding gnemonoside A (3) and resveratrol (6). Gnetin C (2), gnemonoside C (4), and gnemonoside D (5) inhibited the hydrolysis of starch by alpha-amylase from porcine pancreas. An EtOH extract containing these stilbenoids also showed DPPH radical scavenging effect, lipase and alpha-amylase inhibition activity, and antimicrobial activity against food microorganisms and enterobacteria. The present study indicates that melinjo and extracts containing these constituents are useful as health supplements.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sementes
/
Estilbenos
/
Benzofuranos
/
Gnetum
Limite:
Animals
Idioma:
En
Revista:
J Agric Food Chem
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Japão
País de publicação:
Estados Unidos