FTY720 Inhibits Tumor Necrosis Factor-alpha-Induced Proliferation and Extracellular Signal-Regulated Kinase Phosphorylation of Human Smooth Muscle Cells.
Transplant Proc
; 41(2): 705-6, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19328962
ABSTRACT
We investigated the effects of the sphingolipid FTY720 on tumor necrosis factor-alpha (TNF-alpha)-induced proliferation and signal transduction in human smooth muscle cells (SMC). We showed that clinically relevant concentrations of FTY720 inhibited TNF-alpha-induced SMC proliferation and extracellular signal-regulated kinase (ERK) phosphorylation. We concluded that FTY720 may be a useful drug to inhibit chronic vascular rejection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propilenoglicóis
/
Esfingosina
/
Fator de Necrose Tumoral alfa
/
MAP Quinases Reguladas por Sinal Extracelular
/
Rejeição de Enxerto
/
Imunossupressores
/
Músculo Liso
Limite:
Humans
Idioma:
En
Revista:
Transplant Proc
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
França