[Interindividual pharmacokinetic variability in long-term antibiotherapy]. / Variabilité pharmacocinétique intra-individuelle et traitement antibiotique prolongé.
Med Mal Infect
; 40(1): 38-41, 2010 Jan.
Article
em Fr
| MEDLINE
| ID: mdl-19346086
ABSTRACT
OBJECTIVE:
The authors wanted to assess intraindividual pharmacokinetic variability, with a case of long-term amikacin therapy.DESIGN:
A 92-year-old female patient, weighing 44kg, with renal failure, was treated by amikacin for 52 days. Her individual pharmacokinetic parameters were assessed 12 times in the course of therapy. The intraindividual variability of key parameters was quantified and compared with published interindividual variability.RESULTS:
Intraindividual volume and clearance variability was measured at about one fourth to one third of the value observed for interindividual variability. Half-life intraindividual variability was almost equivalent to the interindividual variability 24.5% versus 32%.CONCLUSIONS:
The high pharmacokinetic variability observed has important potential clinical consequences. This case illustrates the need to ensure the effectiveness of treatment, to re-evaluate periodically the patient's status in order to take into account the intraindividual variability of pharmacokinetics parameters.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Amicacina
/
Antibacterianos
Limite:
Aged80
/
Female
/
Humans
Idioma:
Fr
Revista:
Med Mal Infect
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
França