Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes.
Drug Metab Lett
; 2(1): 67-75, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-19356073
ABSTRACT
The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug-drug interactions are likely to occur through either mechanism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Sistema Enzimático do Citocromo P-450
/
Analgésicos
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Drug Metab Lett
Assunto da revista:
FARMACOLOGIA
/
METABOLISMO
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Alemanha
