First Mariner Mos1 transposase inhibitors.
Mini Rev Med Chem
; 9(4): 431-9, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19356121
ABSTRACT
We described chemical inhibitors of Mos1 transposition. Some were already known to affect a related prokaryotic transposase (Tn5) or HIV-1 integrase, whereas the other were new compounds in this field. The new compounds were all organized around a bis-(heteroaryl)maleimides scaffold. Their mechanism of action depended on the chemical substitutions on the scaffold. The cross-activity, between HIV-1 integrase and Mos1 transposase, of the new group of inhibitors showed that Mos1 transposase could constitute an excellent surrogate HIV-1 inhibitor screen.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Integrase de HIV
/
Transposases
/
Proteínas de Ligação a DNA
/
Maleimidas
Idioma:
En
Revista:
Mini Rev Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
França