The emergence of cognitive discrepancies in preclinical Alzheimer's disease: a six-year case study.
Neurocase
; 15(4): 278-93, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19382039
ABSTRACT
We present neuropsychological data from an 81-year-old individual who was followed over a six-year period, initially as a healthy control participant. She performed above age-adjusted cutoff scores for impairment on most neuropsychological tests, including learning and memory measures, until the final assessment when she received a diagnosis of probable Alzheimer's disease (AD). Despite generally normal scores on individual cognitive tests, her cognitive profile revealed increasingly large cognitive discrepancies when contrasting verbal versus visuospatial tasks, and complex versus basic-level tasks. The present case provides intriguing evidence that cognitive-discrepancy measures could improve our ability to detect subtle changes in cognition at the earliest, preclinical stages of AD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Cognitivos
/
Avaliação da Deficiência
/
Doença de Alzheimer
/
Testes Neuropsicológicos
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Aged80
/
Female
/
Humans
Idioma:
En
Revista:
Neurocase
Assunto da revista:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
/
PSICOLOGIA
/
PSIQUIATRIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos