Two different homing pathways involving integrin ß7 and E-selectin significantly influence trafficking of CD4 cells to the genital tract following Chlamydia muridarum infection.
Am J Reprod Immunol
; 61(6): 438-45, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19392981
ABSTRACT
PROBLEM:
Chlamydia trachomatis causes STI and reproductive dysfunction worldwide which is not preventable with antibiotics. Identifying a population of endocervical T cells to target in vaccine development would enhance efficacy. METHOD OF STUDY Trafficking of murine CD4+ lymphocytes to Chlamydia muridarum infected genital tract (GT) tissue in vivo was measured using adoptive transfer studies of fluorescent CD4+ T cells from integrin ß7-/- mice or mice which lack E-selectin on endothelial cells.RESULTS:
Murine in vivo migration studies showed that lack of α4ß7 or E-selectin significantly reduced trafficking of CD4 T cells to the GT of mice infected with C. muridarum.CONCLUSION:
CD4+ T cells use at least two different adhesive mechanisms involving an integrin of the mucosal homing pathway and selectin pathway to accumulate in the GT during C. muridarum infection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
/
Infecções por Chlamydia
/
Movimento Celular
/
Selectina E
/
Chlamydia muridarum
/
Cadeias beta de Integrinas
/
Genitália Feminina
Limite:
Animals
Idioma:
En
Revista:
Am J Reprod Immunol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos