Autoimmune autonomic ganglionopathy: treatment by plasma exchanges and rituximab.
Clin Auton Res
; 19(4): 259-62, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19399547
ABSTRACT
This case report describes successful treatment of autoimmune autonomic ganglionopathy (AAG) in a 74-year-old woman by total plasma exchanges (PLEX) and rituximab. Two series of PLEX temporarily, but dramatically improved orthostatic intolerance and hypotension and baroreflex function, in a manner inversely related to ganglionic neuronal nicotinic receptor antibody titer. After rituximab treatment, the antibody titer was decreased modestly but persistently, and the patient had symptomatic and clinical laboratory evidence of continued benefit for at least 10 months, supporting the autoimmune pathogenesis of AAG.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Troca Plasmática
/
Doenças Autoimunes do Sistema Nervoso
/
Gânglios Autônomos
/
Fatores Imunológicos
/
Anticorpos Monoclonais
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Clin Auton Res
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos