Synthesis of Lewis X epitopes on plant N-glycans.
Carbohydr Res
; 344(12): 1487-93, 2009 Aug 17.
Article
em En
| MEDLINE
| ID: mdl-19515362
ABSTRACT
Glycoproteins from tobacco line xFxG1, in which expression of a hybrid beta-(1-->4)-galactosyltransferase (GalT) and a hybrid alpha-(1-->3)-fucosyltransferase IXa (FUT9a) is combined, contained an abundance of hybrid N-glycans with Lewis X (Le(X)) epitopes. A comparison with N-glycan profiles from plants expressing only the hybrid beta-(1-->4)-galactosyltransferase suggested that the fucosylation of the LacNAc residues in line xFxG1 protected galactosylated N-glycans from endogenous plant beta-galactosidase activity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Nicotiana
/
Plantas Geneticamente Modificadas
/
Epitopos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Carbohydr Res
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Holanda