Presynaptic mechanisms of endocannabinoid-mediated long-term depression in the hippocampus.
J Neurophysiol
; 102(4): 2009-12, 2009 Oct.
Article
em En
| MEDLINE
| ID: mdl-19553483
ABSTRACT
Endogenous cannabinoids (eCBs) mobilized from postsynaptic cells activate presynaptic cannabinoid receptors and thereby inhibit synaptic transmitter release. The inhibition can be either brief (seconds) or long-lasting (minutes to hours). Recent studies provide insight into the presynaptic mechanisms responsible for long-lasting, eCB-mediated long-term depression. Among these, the proteins PKA and RIM1alpha appear to be crucial, although other possibilities are emerging.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terminações Pré-Sinápticas
/
Depressão Sináptica de Longo Prazo
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Endocanabinoides
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Moduladores de Receptores de Canabinoides
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Hipocampo
Limite:
Animals
Idioma:
En
Revista:
J Neurophysiol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos