The use of a Type-I lyophilisate collagen as an osteoinductive factor in pseudarthroses of the forearm.
Surg Technol Int
; 18: 213-8, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19579208
ABSTRACT
The purpose of this study was to assess the use of a novel bone void filler consisting of Type I collagen and various growth factors (VEGF, TGFß-1, TGFß-2, IGF-1, BMP-2, BMP-3, and BMP-7) and surgical fixation to treat diaphyseal forearm pseudarthroses. Eleven patients underwent an osteosynthesis procedure for isolated pseudarthrosis fractures of the forearm (six radial and five ulnar diaphysis). The mean duration between the initial failed surgical fixation and re-operation was 38 weeks. Radiographic signs of fracture healing after the application of the bone void filler were noted at a mean of 5 weeks, and complete fracture consolidation was achieved at a mean of 6 weeks. All patients demonstrated improved range of motion and grip strength. Additionally, all patients were pain-free by 6 weeks. The combination of a novel bovine bone-derived bone void filler and stable internal fixation led to union and rapid healing of forearm pseudarthroses.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pseudoartrose
/
Substitutos Ósseos
/
Colágeno Tipo I
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Regeneração Tecidual Guiada
/
Antebraço
/
Fixação Interna de Fraturas
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Surg Technol Int
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Alemanha