Hemostatic resuscitation during surgery improves survival in patients with traumatic-induced coagulopathy.
J Trauma
; 67(1): 33-7; discussion 37-9, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19590305
ABSTRACT
BACKGROUND:
Although hemostatic resuscitation with a 11 ratio of fresh-frozen plasma (FFP) to packed red blood cells (PRBC) after severe hemorrhage has been shown to improve survival, its benefit in patients with traumatic-induced coagulopathy (TIC) after >10 units of PRBC during operation has not been elucidated. We hypothesized that a survival benefit would occur when early hemostatic resuscitation was used intraoperatively after injury in patients with TIC.METHODS:
A 7-year retrospective study of patients with emergency department diagnosis of TIC after transfusion of >10 units of PRBC in the operating room. TIC was defined as initial emergency department international normalized ratio > 1.2, prothrombin time > 16 seconds, and partial thromboplastin time > 50 seconds. Patients were divided into FFPPRBC ratios of 11, 12, 13, and 14. Patients with diagnosis of TIC who received transfusion of both FFP and PRBC during surgery were included. Other variables evaluated included age, gender, mechanism of injury, initial base deficit, mean operative time, trauma intensive care unit length of stay (TICU LOS) and Injury Severity Score. The primary outcome measure evaluated was the impact of the early FFPPRBC ratio on mortality.RESULTS:
Four hundred thirty-five patients underwent emergency operations postinjury and received FFP with >10 units of PRBC in the operating room; 135 (31.0%) of these patients had TIC and 53 died (39.5% mortality). Mean operative time was 137 minutes (SD +/- 49). There were no differences with regard to age, gender, mechanism of injury, initial base deficit, or Injury Severity Score among all groups. A significant difference in mortality was found in patients who received >10 units of PRBC when FFPPRBC ratio was 11 versus 14 (28.2% vs. 51.1%, p = 0.03). Intermediate mortality rates were noted in patients with 12 and 13 ratios (38% and 40%, respectively). From a linear regression model, 13 days of increased TICU LOS was observed among 14 group compared with 11 group (p < 0.01).CONCLUSION:
TIC is common after severe injury and is associated with a high mortality in patients transfused with >10 units of PRBC during surgery. Early hemostatic resuscitation during first hours after injury improves survival with shorter TICU LOS in patients with TIC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ressuscitação
/
Ferimentos e Lesões
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Técnicas Hemostáticas
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Transfusão de Componentes Sanguíneos
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Coagulação Intravascular Disseminada
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Hemostasia
/
Cuidados Intraoperatórios
Tipo de estudo:
Etiology_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
/
Male
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Trauma
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
/
EUA
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UNITED STATES
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UNITED STATES OF AMERICA
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US
/
USA