The effect of varicocele on seminal plasma and serum inhibin-B levels in adolescent and adult men.
Int Urol Nephrol
; 42(1): 47-51, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-19590975
ABSTRACT
INTRODUCTION:
In the present study, the relationship between serum/seminal plasma and serum FSH and seminal parameters was evaluated in adults and adolescent varicocele patients and compared with normal fertile cases.METHODS:
A total of 50 adult patients with varicocele (Group-1) and 50 adolescents with varicocele (Group-2) were enrolled into the study. Fifty fertile cases without any scrotal pathology were accepted as control group (Group-3). Serum gonadotropin, sex steroids and serum and seminal plasma inhibin-B levels were measured, and semen analysis was performed after 2 and 5 days of sexual abstinence. All parameters were compared among three groups by using one-way ANOVA test.RESULTS:
There were statistically significant differences among three groups on seminal parameters due to disturbed spermatogenesis in patients with varicocele (P < 0.05). However, there were not statistical differences between serum and seminal plasma Inhibin-B levels among groups. In varicocele patients, serum inhibin-B levels showed negative and significant correlation only with FSH levels (r = -0.253, P = 0.011). On the contrary, neither serum nor seminal plasma inhibin-B levels showed significant correlation with seminal parameters.CONCLUSION:
While varicocele affects different mechanisms in the regulation of spermatogenesis in testes, serum and seminal plasma inhibin-B have not any role in decreased spermatogenesis in varicocele.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sêmen
/
Varicocele
/
Inibinas
Limite:
Adolescent
/
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Int Urol Nephrol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Turquia