[Effects of different oxygen flow rates on myocardial ischemia-reperfusion injury in rabbits].
Nan Fang Yi Ke Da Xue Xue Bao
; 29(7): 1477-8, 2009 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-19620086
ABSTRACT
OBJECTIVE:
To explore the effects of different oxygen flow rates during cardiopulmonary bypass (CPB) on myocardial ischemia-reperfusion (IR) injury in rabbits.METHODS:
Thirty rabbits were randomized equally into groups A, B and C to receive controlled oxygen reperfusion at low, normal and high flow rates (25, 50, and 80 ml.kg(-1).min(-1), respectively). Serum concentration of CK-MB and cTnT were tested by ELISA before the operation (T0) and after 30 min (T1), 2 h (T2), 12 h (T3) and 24 h (T4) of reperfusion. W/D, SOD and MDA of the myocardium were determined before and at 60 min after reperfusion. The ultrastructural alterations of the myocardium were observed.RESULTS:
Serum concentration of CK-MB and cTnT in the 3 groups increased significantly after the operation, and their levels were the lowest in group A (P<0.05). W/D and MDA in the myocardium was also the lowest, while SOD the highest in group A (P<0.05). Ultrastructural pathologies were found in all the 3 groups, but relatively mild in group A.CONCLUSION:
Low oxygen flow rate during controlled reperfusion may protect the myocardium from IR injury in rabbits.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Traumatismo por Reperfusão Miocárdica
/
Reperfusão
Limite:
Animals
Idioma:
Zh
Revista:
Nan Fang Yi Ke Da Xue Xue Bao
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
China