Biochemical evaluation of leachate-contaminated groundwater on the kidney of Albino rats.
Exp Toxicol Pathol
; 62(5): 483-8, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-19625173
ABSTRACT
The effect of leachate-contaminated groundwater on the cells of the kidney was evaluated. Serum Na(+) concentration of control rats was observed to be 120+/-1.0 nmol/l while that of rat placed on simulated leachate was 180+/-4.0 nmol/l. Serum K(+), urea and creatinine concentrations of rats placed on simulated leachate and leachate-contaminated groundwater were significantly higher(p<0.05) than those of control rats. The activity of Alkaline phosphatase (ALP) of the kidney and serum, respectively, observed for the control rats were (237+/-3.70 and 0.37+/-0.01)nmol/min/mg protein while (116+/-4.20 and 3.17+/-0.20)nmol/min/mg protein was the ALP activity of kidney and serum, respectively, observed for the rats placed on simulated leachate. Histological examination of the kidney of the control rats showed no visible lesion while that of rats placed on simulated leachate showed extensive necrosis of muscle fibres and cellular infiltration by macrophages. It is viewed that leachate-contaminated groundwater may damage kidney cells and impair renal function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poluentes Químicos da Água
/
Rim
Limite:
Animals
Idioma:
En
Revista:
Exp Toxicol Pathol
Assunto da revista:
PATOLOGIA
/
TOXICOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Nigéria