Open muscle biopsy in suspected myopathy: diagnostic yield and clinical utility.
Eur J Neurol
; 17(1): 136-42, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19674068
ABSTRACT
BACKGROUND:
The purpose of the study was to investigate the diagnostic yield and clinical utility of open muscle biopsy and to identify pre-biopsy factors that might predict useful clinical results for suspected myopathy.METHODS:
Two-hundred fifty-eight muscle biopsies, performed for investigation of suspected myopathy, were evaluated.RESULTS:
A specific clinical diagnosis following muscle biopsy was made in 43% of cases. As a result of the biopsy, clinical diagnosis was changed in 47% and treatment was changed in 33% of cases. Results either led to a specific clinical diagnosis or changed the diagnosis/treatment in 74% of patients. Positive family history of myopathy and findings of myopathic irritability on electromyography had a negative predictive value for diagnosis change.CONCLUSIONS:
Open muscle biopsy is useful in myopathy evaluation in the modern genetic era.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Músculo Esquelético
/
Doenças Musculares
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Eur J Neurol
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Taiwan