[Neuropathology and molecular pathology of gliomas]. / Neuropathologie et pathologie moléculaire des gliomes.
Rev Med Suisse
; 5(211): 1501-4, 2009 Jul 15.
Article
em Fr
| MEDLINE
| ID: mdl-19694359
ABSTRACT
Gliomas are the most frequent primary brain tumours. The WHO classification is essentially based on histological and immunohistochemical criteria. More recently multiple cytogenetic and molecular alterations associated with initiation and progression have been shown and the genetic profiles of tumour entities have been incorporated in the WHO classifiacation. Molecular testing of the MGMT promotor methylation in glioblastoma, predictive for the response to combined radio-/chimiothérapie, and the LOH 1p/19q in oligodendroglial tumours, as prognostic factor supplements the histopathological diagnosis. In the near futur array-based profiling techniques will contribute to a refinement of glioma classification and identify targets for more individualized glioma therapies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Sistema Nervoso Central
/
Glioma
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Fr
Revista:
Rev Med Suisse
Assunto da revista:
MEDICINA
Ano de publicação:
2009
Tipo de documento:
Article