The glutamate switch is present in all seven clades of AAA+ protein.
Biochemistry
; 48(37): 8774-5, 2009 Sep 22.
Article
em En
| MEDLINE
| ID: mdl-19702328
ABSTRACT
Recent work has identified a "glutamate switch" in six of the seven clades of AAA+ ATPases. The glutamate switch acts to transduce information regarding substrate binding to the ATPase active site. We provide biochemical evidence that a highly conserved threonine residue acts as a glutamate switch in the replicative helicase, MCM, and, thus, reveal that the glutamate switch is a feature common to all seven AAA+ clades.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Glutâmico
/
Proteínas Arqueais
/
Proteína 1 de Manutenção de Minicromossomo
/
Homologia Estrutural de Proteína
/
DnaB Helicases
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Biochemistry
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Reino Unido