Sexual dimorphism in the adolescent brain: Role of testosterone and androgen receptor in global and local volumes of grey and white matter.
Horm Behav
; 57(1): 63-75, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19703457
ABSTRACT
Here we examined sex differences in the volumes of grey and white matter, and in grey-matter "density," in a group of typically developing adolescents participating in the Saguenay Youth Study (n=419; 12-18 years). In male adolescents, we also investigated the role of a functional polymorphism in androgen-receptor gene (AR) in moderating the effect of testosterone on volumes of grey and white matter and grey-matter density. Overall, both absolute and relative volumes of white matter were larger in male vs. females adolescents. The relative grey-matter volumes were slightly larger in female than male adolescents and so was the grey-matter density in a large number of cortical regions. In male adolescents, functional polymorphism of AR moderated the effect of testosterone on relative white- and grey-matter volumes. Following a discussion of several methodological and interpretational issues, we outline future directions in investigating brain-behavior relationships vis-à-vis psychopathology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testosterona
/
Córtex Cerebral
/
Puberdade
/
Caracteres Sexuais
/
Desenvolvimento do Adolescente
Limite:
Adolescent
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Horm Behav
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Reino Unido