Morphological comparison of small nerve fibres in gastric mucosa in non-diabetic and Type 2 diabetic subjects.
Diabet Med
; 26(9): 943-6, 2009 Sep.
Article
em En
| MEDLINE
| ID: mdl-19719718
ABSTRACT
AIM:
To determine changes in small nerve fibres in gastric mucosa in patients with Type 2 diabetes by morphological observation.METHODS:
In twenty-five non-diabetic and 21 Type 2 diabetic participants, gastric mucosal biopsy under endoscopy was performed. Innervation in gastric mucosa was detected using immunohistochemical staining. Anti-protein gene product (PGP) 9.5 positive nerves underwent morphological observation and quantitative analysis.RESULTS:
Small nerve fibres in gastric mucosa were shortened in the diabetic subjects. The ratio of gastric mucosal protrusions maintaining nerve fibres between gastric pits to total observed protrusions was lower in patients with Type 2 diabetes compared with the non-diabetic subjects (ratio of innervated protrusion/total protrusion 0.49 +/- 0.12 vs. 0.89 +/- 0.06, P < 0.05).CONCLUSIONS:
This study sets the scene for further research to investigate the relationship between gastric mucosal nerves and autonomic neuropathy or diabetic peripheral neuropathy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 2
/
Mucosa Gástrica
/
Fibras Nervosas
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Diabet Med
Assunto da revista:
ENDOCRINOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Coréia do Sul