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Practical syntheses of 4-fluoroprolines.
J Fluor Chem ; 129(9): 781-784, 2008 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19727323
ABSTRACT
4-Fluoroprolines are among the most useful nonnatural amino acids in chemical biology. Here, practical routes are reported for the synthesis of the 2S,4R, 2S,4S, and 2R,4S diastereomers of 4-fluoroproline. Each route starts with (2S,4R)-4-hydroxyproline, which is a prevalent component of collagen and hence readily available, and uses a fluoride salt to install the fluoro group. Hence, the routes provide process-scale access to these useful nonnatural amino acids.

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Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: J Fluor Chem Ano de publicação: 2008 Tipo de documento: Artigo País de afiliação: Estados Unidos