Application of the radioreceptor assay for human chorionic gonadotropin in pregnancy testing and management of trophoblastic disease.
Obstet Gynecol
; 50(3): 324-32, 1977 Sep.
Article
em En
| MEDLINE
| ID: mdl-197458
ABSTRACT
A commercially prepared radioreceptor assay (RRA) for human chorionic gonadotropin (hCG) has been evaluated as a pregnancy test and in a quantitative assay to follow patients with hydatidiform mole. The RRA demonstrated almost 100% agreement in comparison with radioimmunoassay (RIA) and urinary hCG tests. In the quantitative assay, a limiting reliable concentration of 70 mIU/ml of hCG in serum could be obtained. Extremely good correlation was achieved between the RRA and RIA test for hCG in 2 patients with hydatidiform mole over a span of 3 months of followup after evacuation of the mole. The usefulness of the RRA as a replacement of RIA tests for hCG is discussed.
ABSTRACT
PIP The use of a commercially prepared radioreceptor assay (RRA) for human chorionic gonadotropin (HCG) as a pregnancy test and in the follow-up of patients with hydatidiform mole is reported. In comparison with radioimmunoassay (RIA) and urinary HCG tests, the RRA gave results that were almost in 100% agreement. In 2 patients who were followed for 3 months after evacuation of a hydatidiform mole, the RRA and RIA showed an extremely good correlation. The limiting reliable concentration in the quantitative RRA assay was 70 mIU/ml of HCG in serum. The advantages and disadvantages of the RRA and RIA in a general hospital laboratory are discussed.
Palavras-chave
Biology; Clinical Research; Comparative Studies; Endocrine System; Evaluation; Examinations And Diagnoses; Gonadotropins; Gonadotropins, Chorionic--analysis; Hormones; Laboratory Examinations And Diagnoses; Laboratory Procedures; Physiology; Pregnancy Tests; Pregnancy Tests, Immunologic; Research Methodology; Studies
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ensaio Radioligante
/
Neoplasias Uterinas
/
Testes Imunológicos de Gravidez
/
Neoplasias Trofoblásticas
/
Gonadotropina Coriônica
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Obstet Gynecol
Ano de publicação:
1977
Tipo de documento:
Article