The role of the prostatic stroma in chronic prostatitis/chronic pelvic pain syndrome.
Inflamm Res
; 58(12): 829-36, 2009 Dec.
Article
em En
| MEDLINE
| ID: mdl-19757087
ABSTRACT
OBJECTIVE:
To confirm the hypothesis of prostatic stromal involvement in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). MATERIALS ANDMETHODS:
A literature review to analyze mechanisms commonly indicated as a cause of CP/CPPS that can interfere with the processes of cell growth of smooth muscle fibrocells and may cause smooth muscle cell hypertrophy, periurethral edema, and inflammation.RESULTS:
Our review strongly suggests a prevalent stromal involvement, specifically of the smooth muscle cells, in CP/CPPS physiopathology. The involvement of the endocrine system, in particular the role of estrogens, the neurological pathway mediated by noradrenalin, and the presence of inflammation, support the hypothesis that CP/CPPS could be a disease with a prevalent role of smooth muscle stromal cells rather than glandular structures. Neurogenous inflammation, oxidative stress and psychological factors may be involved in the chronic nature of the disease.CONCLUSIONS:
We believe that new studies regarding chronic prostatitis should also be focused on prostatic stromal involvement in the inflammatory pathway.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Próstata
/
Prostatite
/
Células Estromais
/
Dor Pélvica
/
Inflamação
Limite:
Animals
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Inflamm Res
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Itália