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Plasma fibrinogen levels and prognosis in patients with ovarian cancer: a multicenter study.
Polterauer, Stephan; Grimm, Christoph; Seebacher, Veronika; Concin, Nicole; Marth, Christian; Tomovski, Caroline; Husslein, Heinrich; Leipold, Heinz; Hefler-Frischmuth, Katrin; Tempfer, Clemens; Reinthaller, Alexander; Hefler, Lukas.
Afiliação
  • Polterauer S; Department of Obstetrics & Gynecology, Medical University of Vienna, Waehringer Guer 18-20, A-1090 Vienna, Austria. stephan.polterauer@meduniwien.ac.at
Oncologist ; 14(10): 979-85, 2009 Oct.
Article em En | MEDLINE | ID: mdl-19776095
INTRODUCTION: To evaluate pretherapeutic plasma fibrinogen levels as a prognostic parameter in patients with epithelial ovarian cancer (EOC). Materials and Methods. In the present multicenter study, pretherapeutic plasma fibrinogen levels were evaluated in 422 patients with EOC. Plasma fibrinogen levels were correlated with clinicopathological parameters and patient survival. RESULTS: The mean (standard deviation) pretherapeutic plasma fibrinogen level was 450.0 (150.1) mg/dl. Elevated plasma fibrinogen levels were associated with advanced tumor stage (p = .01) and the presence of a postoperative residual tumor mass (p < .001), but not with histological grade (p = .1) and histological type (p = .8). In a multivariate Cox regression model, tumor stage (p < .001 and p < .001), postoperative residual tumor mass (p = .001 and p = .008), and plasma fibrinogen level (p < .001 and p = .002), but not histological type (p = .8 and p = .2), patient age (p = .9 and p = .9), and serum cancer antigen 125 (p = 0.2 and p = 0.3) and C-reactive protein (p = .2 and p = .3) levels, were associated with disease-free and overall survival, respectively. Histological grade was associated with overall but not with disease-free survival (p = .01 and p = .8), respectively. CONCLUSIONS: Pretherapeutic plasma fibrinogen levels can be used as an independent prognostic parameter in patients with EOC.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Fibrinogênio Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: En Revista: Oncologist Assunto da revista: NEOPLASIAS Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Áustria País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Fibrinogênio Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: En Revista: Oncologist Assunto da revista: NEOPLASIAS Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Áustria País de publicação: Reino Unido