Mesenchymal stem cells are functionally abnormal in patients with immune thrombocytopenic purpura.
Cytotherapy
; 11(6): 698-705, 2009.
Article
em En
| MEDLINE
| ID: mdl-19878056
ABSTRACT
BACKGROUND AIMS:
Immune thrombocytopenic purpura (ITP) is a bleeding disorder characterized by an accelerated destruction of platelets as a result of the presence of autoreactive antibodies. Patients with ITP also display activated platelet-autoreactive T cells. Mesenchymal stem cells (MSC) inhibit both T- and B-cell activation and may have functional impairments in autoimmune disorders.METHODS:
We analyzed the potential role of MSC in the pathogenesis of ITP.RESULTS:
MSC from ITP showed an impaired proliferative capacity and a lower capability of inhibiting activated T-cell proliferation compared with healthy donors. While MSC from controls showed a decreased expression of p27 after stimulation with platelet-derived growth factor, this effect was not observed in MSC from patients. Furthermore, MSC from healthy donors down-regulated p16 upon exposure to platelet-released supernatant, while this effect was not observed for ITP. Interestingly, caspase 9 expression was higher in MSC from ITP.CONCLUSIONS:
These abnormalities suggest a role of MSC malfunction in the physiopathology of the disease and may have therapeutic implications.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Linfócitos T
/
Púrpura Trombocitopênica Idiopática
/
Inibidor p16 de Quinase Dependente de Ciclina
/
Caspase 9
/
Células-Tronco Mesenquimais
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Cytotherapy
Assunto da revista:
TERAPEUTICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Espanha