Evaluation of rotavirus vaccines in Asia--are there lessons to be learnt?
Vaccine
; 27 Suppl 5: F120-9, 2009 Nov 20.
Article
em En
| MEDLINE
| ID: mdl-19931711
ABSTRACT
Rotavirus mortality is highest in the Asia-Pacific region and rotavirus vaccines could have enormous impact here. Yet, live-attenuated orally administered rotavirus vaccines have been evaluated in a small number of immunogenicity studies in some Asian countries, where the immune responses have been documented to be moderate in low-income countries with high diarrhoeal disease burden and mortality, and high in middle-/high-income countries with little reported rotavirus deaths. This review of these rotavirus clinical trials examines the results observed and attempts to draw lessons to inform decision-making, aid design of additional clinical trials and guide vaccine development by local manufacturers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Rotavirus
/
Vacinação
/
Vacinas contra Rotavirus
/
Diarreia
Tipo de estudo:
Prognostic_studies
Limite:
Humans
/
Infant
País/Região como assunto:
Asia
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
França
País de publicação:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS