[The relationship between monocyte chemoattractant protein-1 gene polymorphisms and the susceptibility to pulmonary tuberculosis].
Zhonghua Jie He He Hu Xi Za Zhi
; 32(6): 454-6, 2009 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-19957783
ABSTRACT
OBJECTIVE:
To explore the possible relationship between the -2518 A/G single nucleotide polymorphisms in monocyte chemoattractant protein-1 (MCP-1) gene of Chinese Han population and the susceptibility to pulmonary tuberculosis.METHODS:
A 11 matched case-control study was conducted from March 2008 to August 2008. The - 2518 MCP-1 A/G polymorphisms were detected in 167 pairs of subjects by reaction-restriction fragment length polymorphism (PCR-RLFP) technique. General characteristics, current disease history, past medical history and related environmental factors of tuberculosis were collected using a questionnaire designed by ourselves. Univariate analyses and multivariate conditional logistic analyses were conducted.RESULTS:
The genotype frequencies of AA, GA and GG in the case group and the control group were 21/167 (12.6%), 62/167 (37.1%), 84/167 (50.3%) and 42/167 (25.2%), 83/167 (49.7%), 42/167 (25.1%), respectively. There was a significant difference in genotype frequencies between the case and the control groups in the univariate analysis (chi2 = 24.041, P<0.01). The significant association remained after adjusting environmental factors between genotype GG (OR 1.989, 95% CI 1.154 - 3.428, chi2 = 6.124, P<0.05) and the susceptibility to pulmonary tuberculosis.CONCLUSION:
The -2518 MCP-1 GG genotype might be associated with susceptibility to pulmonary tuberculosis in Chinese Han population.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose Pulmonar
/
Quimiocina CCL2
/
Polimorfismo de Nucleotídeo Único
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Jie He He Hu Xi Za Zhi
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
China