PathGen: a transitive gene pathway generator.
Bioinformatics
; 26(3): 423-5, 2010 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-19965882
ABSTRACT
SUMMARY:
Many online sources of gene interaction networks supply rich visual data regarding gene pathways that can aid in the study of biological processes, disease research and drug discovery. PathGen incorporates data from several sources to create transitive connections that span multiple gene interaction databases. Results are displayed in a comprehensible graphical format, showing gene interaction type and strength, database source and microarray expression data. These features make PathGen a valuable tool for in silico discovery of novel gene interaction pathways, which can be experimentally tested and verified. The usefulness of PathGen interaction analyses was validated using genes connected to the altered facial development related to Down syndrome.AVAILABILITY:
http//dna.cs.byu.edu/pathgen. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online. Further information is available at http//dna.cs.byu.edu/pathgen/PathGenSupplemental.pdf.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Software
/
Biologia Computacional
/
Redes Reguladoras de Genes
Idioma:
En
Revista:
Bioinformatics
Assunto da revista:
INFORMATICA MEDICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos