[Is bioptic assurance reasonable in patients with Sjögren's syndrome? From focus score to diagnosing vasculitides]. / Ist eine bioptische Sicherung beim Sjögren-Syndrom sinnvoll? Vom Focus-Score zur Vaskulitisdiagnostik.
Z Rheumatol
; 69(1): 11-8, 2010 Feb.
Article
em De
| MEDLINE
| ID: mdl-19997922
ABSTRACT
Sjögren's syndrome is an autoimmune disease which targets the salivary and lacrimal glands in particular, causing sicca syndrome. Extraglandular manifestations are often seen. Chronic sialadenitis of the parotid gland is the most common symptom to be assessed for differential diagnosis. Common HE and Giemsa slices are histopathologically examined and graduated for lymphocyte infiltration (focus) grade 0 absent, grade 1 slight, grade 2 moderate non-focal infiltration, grade 3 1 focus (> or =50 lymphocytes) per 4 mm2, grade 4 >1 focus. Grade 3 infiltrates correspond to a focus score of 1, which is one of four disease-classifying criteria acknowledged for diagnosis. Bioptic examination is also performed to rule out different (non-) immunologic sialadenitises, such as the necrotizing or epithelioid-like form (in sarcoidosis), and the extranodal marginal-zone lymphoma. Extraglandular manifestations of Sjögren's syndrome can also be safely diagnosed by histopathological examination. Emphases lie on vasculitides and myositides. Bioptic work-up, therefore, is not only reasonable but also an essential tool for diagnostics in Sjögren's syndrome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sialadenite
/
Vasculite
/
Síndrome de Sjogren
/
Ceratoconjuntivite Seca
/
Miosite
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
De
Revista:
Z Rheumatol
Ano de publicação:
2010
Tipo de documento:
Article